Key result
Administration of prothrombin complex concentrate in patients with warfarin-associated intracranial hemorrhage reduced the required dose of fresh frozen plasma within 24 hours compared to control.
Why the study?
Does prothrombin complex concentrate reduce FFP requirement and rapidly correct PT-INR in patients with warfarin-associated intracranial hemorrhage?
Cohort (n=19)
No
Does prothrombin complex concentrate reduce FFP requirement and rapidly correct PT-INR in patients with warfarin-associated intracranial hemorrhage?
Answers are grounded in this paper and cite their sources.
Prothrombin complex concentrate rapidly reverses PT-INR and significantly reduces the need for fresh frozen plasma in patients with warfarin-associated intracranial hemorrhage, though it did not significantly improve 1-month clinical outcomes in this small cohort.
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Iba et al. (2013) conducted a cohort in Warfarin-associated intracranial hemorrhage (n=19). Prothrombin complex concentrate vs. Fresh frozen plasma was evaluated on Amount of fresh frozen plasma (FFP) administered within 24 hours (ml) (MD -790, p=<0.05). Administration of prothrombin complex concentrate in patients with warfarin-associated intracranial hemorrhage reduced the required dose of fresh frozen plasma within 24 hours compared to control.
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