Why the study?
Does dual-blockade treatment with candesartan and lisinopril reduce systolic blood pressure compared to high-dose lisinopril monotherapy in hypertensive patients with diabetes?
Population
75 type 1 and type 2 diabetic patients aged 35-74 years with hypertension
Comparison
Dual-blockade treatment with candesartan 16 mg… vs Lisinopril 40 mg once daily
Design
RCT, randomized, parallel-group, double-blind, double-dummy
Follow-up
12 months
Authors
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Monotherapy achieves comparable BP control to dual blockade in diabetic hypertension; challenges routine combination use and guides future single-agent optimization trials.
Does dual-blockade treatment with candesartan and lisinopril reduce systolic blood pressure compared to high-dose lisinopril monotherapy in hypertensive patients with diabetes?
Dual blockade with candesartan and lisinopril did not significantly reduce systolic blood pressure more than high-dose lisinopril monotherapy in hypertensive patients with diabetes.
Andersen et al. (2005) studied this question.
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