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This preclinical study investigates the distinct roles of myofibroblast and myocyte β2-adrenoceptors in heart failure and fibrotic remodeling using transgenic mouse models.
Figure. Divergent actions of myofibroblast and myocyte 2 -adrenoceptor ( 2 AR) in heart failure and fibrotic remodeling. A, Quantification of body weights during 6 months high fat diet (HFD) in 2 AR-flox and 2 AR-cKO and fKO transgenic mice. Plasma glucose levels were measured after a 6-hour fast followed by intraperitoneal injection of glucose (1 g/kg), and cardiac function was measured by echocardiography, including ejection fraction (EF), E/A ratio (ratio of the early [E] to late [A] ventricular filling velocities), and isovolumic relaxation time (IVRT). B, Picrosirius-red staining for collagen in heart tissue was imaged and quantified; heart weights were normalized to tibia lengths. C, RNA sequencing analysis of 2 ARflox, cKO, and fKO mouse hearts after normal chow (NC) and HFD feeding. (Continued )
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Deng et al. (2022) studied Heart failure and fibrotic remodeling. High fat diet and beta-2-adrenoceptor knockout vs. Normal chow and flox control was evaluated.
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