The minimum anesthetic concentration of isoflurane varies across pediatric age groups, peaking at 1-6 months of age and being lower than predicted in neonates.
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Age-adjusted isoflurane MAC may refine pediatric dosing; leaves open prospective validation in neonates.
The minimum anesthetic concentration (MAC) of isoflurane was determined in five pediatric age groups. MAC was 1.6% in infants 0-1 month of age, 1.87% in those 1-6 months of age, 1.8% in those 6-12 months of age, 1.6% in those 1-3 yr of age, and 1.6% in children 3-5 yr of age. MAC in neonates was less than predicted.
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Cameron et al. (1984) studied this question.
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