Key result
Isoflurane minimum anesthetic concentration peaks at ~1.9% in infants aged one to six months.
Why the study?
The minimum anesthetic concentration of isoflurane in different pediatric age groups was not well established.
Population
Children in five pediatric age groups from 0 to 5 years
Comparison
Isoflurane concentrations across age groups
Design
Observational study determining MAC
Authors
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May warrant age-specific isoflurane dosing in infants; leaves open larger confirmatory studies.
The minimum anesthetic concentration of isoflurane varies by pediatric age group, peaking at 1-6 months and being lower than predicted in neonates.
Cameron et al. (1984) studied this question. Isoflurane minimum anesthetic concentration peaked at 1.87% in infants aged 1-6 months, compared to 1.8% at 6-12 months and 1.6% in neonates and children aged 1-5 years.
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