Key result
Modified tissue Doppler imaging parameters from the first active wall motion improved prediction of cardiac resynchronization therapy responders (AUC 0.87) compared to original parameters (AUC 0.65).
Why the study?
Do modified TDI dyssynchrony parameters derived from the first active wall motion improve the prediction of responders to CRT in patients with heart failure?
Population
61 consecutive patients with drug-refractory symptomatic heart failure undergoing cardiac resynchronization…
Comparison
Modified tissue Doppler imaging dyssynchrony… vs Original TDI dyssynchrony parameters restricted…
Design
Cohort
Follow-up
6 months
Authors
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May refine CRT responder prediction in HF; hypothesis-generating and requires prospective validation before practice change.
Observational (n=61)
No
Do modified TDI dyssynchrony parameters derived from the first active wall motion improve the prediction of responders to CRT in patients with heart failure?
Effect estimate: AUC 0.87 vs 0.65
Absolute Event Rate: 0.87% vs 0.65%
p-value: p=<0.05
Modified TDI dyssynchrony parameters derived from the first active wall motion significantly improve the prediction of echocardiographic response to CRT compared to conventional TDI parameters.
Sakamaki et al. (2012) conducted an observational in Heart failure with ventricular delay undergoing cardiac resynchronization therapy (n=61). Modified tissue Doppler imaging (TDI) dyssynchrony parameters vs. Original TDI parameters was evaluated on Prediction of CRT responders (LV end-systolic volume reduction >15% at 6 months) (AUC 0.87 vs 0.65, p=<0.05). Modified tissue Doppler imaging parameters from the first active wall motion improved prediction of cardiac resynchronization therapy responders (AUC 0.87) compared to original parameters (AUC 0.65).
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