Key result
Tissue synchronisation imaging accurately measures LV dyssynchrony and predicts post-CRT reverse remodelling with 89% specificity.
Why the study?
Does tissue synchronisation imaging accurately measure left ventricular dyssynchrony and predict response to cardiac resynchronisation therapy compared to manual tissue Doppler imaging in heart failure patients?
Population
60 symptomatic patients with heart failure with depressed left ventricular ejection fraction and QRS >120 ms
Comparison
Automatic assessment of left ventricular… vs Manual assessment of left ventricular…
Design
Cohort
Follow-up
6 months
Authors
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May support automated TSI for dyssynchrony assessment in CRT candidates; extends manual TDI data but leaves open impact on selection in prospective trials.
Observational (n=60)
Does tissue synchronisation imaging accurately measure left ventricular dyssynchrony and predict response to cardiac resynchronisation therapy compared to manual tissue Doppler imaging in heart failure patients?
Effect estimate: r = 0.95
p-value: p=<0.001
Tissue synchronisation imaging provides an automated, reliable alternative to manual tissue Doppler imaging for assessing LV dyssynchrony and accurately predicts reverse remodeling following cardiac resynchronisation therapy.
Veire et al. (2007) conducted an observational in Heart failure with depressed LVEF and QRS >120 ms (n=60). Tissue synchronisation imaging (TSI) vs. Manual assessment from colour-coded tissue Doppler imaging (TDI) was evaluated on Correlation between LV dyssynchrony measured manually and automatically derived by TSI (r = 0.95, p=<0.001). Tissue synchronisation imaging accurately measured left ventricular dyssynchrony (r=0.95 vs manual assessment) and predicted reverse LV remodelling after CRT with 81% sensitivity and 89% specificity.
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