Why the study?
Does the combination of an ETA/ETB receptor antagonist and an AT1-receptor antagonist improve blood pressure reduction in hypertensive rat models?
Does the combination of an ETA/ETB receptor antagonist and an AT1-receptor antagonist improve blood pressure reduction in hypertensive rat models?
Combined ETA/ETB and AT1 receptor blockade provides additive or potentiated antihypertensive effects in rat models of hypertension, suggesting a potential therapeutic strategy for treatment-resistant hypertension.
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Supports combined ETA/ETB-AT1 blockade in resistant hypertension models; leaves open translation to human therapy.
Ikeda et al. (2000) studied this question.
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