January 1, 2000Journal of Cardiovascular Pharmacology
Antihypertensive Effects of a Mixed Endothelin-A- and -B-Receptor Antagonist, J-104132, Were Augmented in the Presence of an AT1-Receptor Antagonist, MK-954
Why the study?
Does J-104132 alone or combined with MK-954 reduce blood pressure in hypertensive rat models?
Population
Conscious spontaneously hypertensive rats, stroke-prone SHR, and Dahl salt-sensitive hypertensive rats fed…
Comparison
J-104132 3 and 10 mg/kg single oral… vs null
Design
Preclinical
Follow-up
approximately 24 h
Authors
Discussion
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Member takes
Implication
Supports dual endothelin-AT1 antagonism in hypertensive rat models; leaves open translation to human therapy.
Structured PICO
Does J-104132 alone or combined with MK-954 reduce blood pressure in hypertensive rat models?
P
Population
Conscious spontaneously hypertensive rats (SHR), stroke-prone SHR (SHRSP), and Dahl salt-sensitive hypertensive rats fed high-salt diet (DS-H)
I
Intervention
J-104132 (mixed ETA/ETB receptor antagonist) 3 and 10 mg/kg single oral administration, alone or in combination with MK-954 (Losartan) 3 and 10 mg/kg
C
Comparator
null
O
Outcome
Blood pressuresurrogate
The combination of an endothelin receptor antagonist and an AT1-receptor antagonist provides additive or potentiated antihypertensive effects in rat models of hypertension.
Cite This Study
Ikeda et al. (2000) studied this question.