Why the study?
Does J-105859 reduce mortality in salt-loaded Dahl salt-sensitive rats?
Does J-105859 reduce mortality in salt-loaded Dahl salt-sensitive rats?
The selective ETA receptor antagonist J-105859 markedly reduced mortality and inhibited the development of hypertension and brain lesions in a rat model of salt-sensitive hypertension.
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J-105859 improves survival in Dahl salt-sensitive rats; leaves open whether ETA antagonism benefits human salt-sensitive hypertension.
Okada et al. (2000) studied this question.
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