Key result
Chronic Angiotensin II infusion in mice significantly increased fractional reabsorption of distal sodium delivery compared to controls (91.1% vs 77.9%; P<0.05).
Why the study?
Does chronic Ang II infusion enhance distal nephron sodium reabsorption in mice?
Does chronic Ang II infusion enhance distal nephron sodium reabsorption in mice?
Absolute Event Rate: 91.1% vs 77.9%
p-value: p=<0.05
Chronic Ang II infusion in mice enhances distal sodium reabsorption dependent on sodium channel and Na-Cl cotransporter activity.
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Extends mechanistic understanding of Ang II in mouse distal nephron; leaves open translation to human hypertension.
Zhao et al. (2009) studied Hypertension / Angiotensin II infusion model (n=23). Chronic Angiotensin II infusion vs. Control was evaluated on Fractional reabsorption of distal sodium delivery (p=<0.05). Chronic Angiotensin II infusion in mice significantly increased fractional reabsorption of distal sodium delivery compared to controls (91.1% vs 77.9%; P<0.05).
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