Why the study?
Does temporary interruption of long-term cardiac resynchronization therapy worsen haemodynamic parameters and mitral regurgitation in patients with LV dysfunction and heart failure?
Population
n=20 patients with LV dysfunction and NYHA class III or IV heart failure despite optimal medical therapy and…
Comparison
Temporary cessation of long-term continuous… vs Baseline state during continuous long-term CRT.
Design
Cohort
Follow-up
72 hours after cessation
Authors
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CRT withdrawal linked to acute LV deterioration and MR worsening; supports uninterrupted pacing but leaves open long-term outcome benefits.
Does temporary interruption of long-term cardiac resynchronization therapy worsen haemodynamic parameters and mitral regurgitation in patients with LV dysfunction and heart failure?
Temporary cessation of long-term biventricular pacing leads to rapid deterioration in LV systolic performance and worsening of functional mitral regurgitation, supporting the need for indefinite CRT maintenance.
Brandt et al. (2005) studied this question.