Key result
Prehypertension was associated with insulin resistance, demonstrating an.435 for HOMA-IR ≥3.76 compared to <1.64.
Why the study?
Is prehypertension associated with insulin resistance in the Mongolian population?
Observational (n=2,553)
Is prehypertension associated with insulin resistance in the Mongolian population?
Prehypertension is significantly associated with insulin resistance in the Mongolian population, suggesting insulin resistance may play a role in the development of hypertension.
Answers are grounded in this paper and cite their sources.
Supports prehypertension-insulin resistance link in Mongolians; hypothesis-generating and should not yet change practice.
BACKGROUND: There is little knowledge on association of prehypertension with insulin resistance among Mongolian people. The purpose of the present study is to explore whether there are phenomena of insulin resistance in the phase of prehypertension in the Mongolian population. METHODS: 2553 Mongolian people were included in the present analysis. Data on demographic characteristics, lifestyle risk factors, family history of hypertension and medical history were obtained, blood pressure, body weight, height and waist circumference measured, fasting blood samples collected and blood lipids, fast plasma glucose and insulin determined for all individuals. RESULTS: Among participants who are overweight, the means of the homeostatic model assessment of insulin resistance (HOMA-IR) were significantly higher in prehypertensives than those in normotensives. Prehypertension was significantly associated with the higher levels of HOMA-IR after multivariate adjustment. Compared with HOMA-IRs < 1.64, multivariate-adjusted ORs (95% CI) for HOMA-IRs of 1.64-2.32, 2.33-2.84, 2.85-3.76 and ≥3.76 were 1.056 (0.786-1.418), 1.565 (1.158-2.116), 1.381 (1.020-1.870) and 1.435 (1.046-1.970), respectively. CONCLUSIONS: Prehypertension was significantly associated with insulin resistance in the Mongolian population, and this study suggest that insulin resistance may play an important role in development of hypertension.
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Zhao et al. (2010) conducted an observational in Prehypertension and insulin resistance (n=2,553). Prehypertension vs. Normotension was evaluated on Insulin resistance (HOMA-IR ≥3.76 vs <1.64) (OR 1.435, 95% CI 1.046-1.970). Prehypertension was associated with insulin resistance, demonstrating an.435 for HOMA-IR ≥3.76 compared to <1.64.
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