Key result
The PDE4D gene G0 haplotype and AC008818-1 allele 148 were significantly associated with an increased risk of ischaemic stroke in a Greek population.
Why the study?
Is the phosphodiesterase 4D (PDE4D) gene G0 haplotype associated with ischaemic stroke in a Greek population?
Population
Greek patients with ischaemic stroke and control individuals with no clinical manifestations of vascular…
Comparison
Presence of phosphodiesterase 4D single… vs Absence of these specific alleles/haplotypes
Design
Case-control
Authors
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Supports PDE4D as stroke risk marker in Greeks; leaves open replication and clinical utility.
Case-Control
Is the phosphodiesterase 4D (PDE4D) gene G0 haplotype associated with ischaemic stroke in a Greek population?
The study independently confirms the association of a PDE4D gene haplotype with ischaemic stroke in a Greek population, suggesting its involvement in stroke pathogenesis.
Fidani et al. (2007) conducted a case-control in Ischaemic stroke. PDE4D gene G0 haplotype and AC008818-1 alleles vs. Absence of the haplotype/alleles was evaluated on Ischaemic stroke. The PDE4D gene G0 haplotype and AC008818-1 allele 148 were significantly associated with an increased risk of ischaemic stroke in a Greek population.
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