Key result
PDE4D gene variants show no association with ischaemic stroke risk.
Why the study?
Genetic association between six SNPs in the PDE4D gene and ischaemic stroke was previously demonstrated in an Icelandic cohort but not tested in a large German cohort.
Are six single nucleotide polymorphisms in the PDE4D gene associated with ischaemic stroke in a German cohort?
Population
1181 patients with acute completed ischaemic stroke and 1569 population-based controls from northern Germany
Comparison
Presence of six SNPs in PDE4D gene vs absence in controls
Design
Case-control study
Authors
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Does not support PDE4D genotyping for ischaemic stroke risk; challenges prior associations and leaves replication in other populations open.
Case-Control (n=2,750)
Are six single nucleotide polymorphisms in the PDE4D gene associated with ischaemic stroke in a German cohort?
This study failed to replicate the previously reported association between six SNPs in the PDE4D gene and ischaemic stroke in a large German cohort.
Gregor Kuhlenbäumer (2006) conducted a case-control in Ischaemic stroke (n=2,750). Six single nucleotide polymorphisms (SNPs) in the PDE4D gene vs. Population-based controls was evaluated on Ischaemic stroke. Six single nucleotide polymorphisms in the PDE4D gene showed no significant association with ischaemic stroke in a German cohort of 1,181 stroke patients and 1,569 controls.
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