Why the study?
Are Phosphodiesterase 4D (PDE4D) polymorphisms associated with incident ischemic stroke in elderly white women, and does hypertension status modify this association?
Population
808 elderly white women from the Study of Osteoporotic Fractures in the United States, including 248 who…
Comparison
13 single-nucleotide polymorphisms and 1… vs Different genotypes/alleles
Design
Case-control
Follow-up
average 5.4 years
Authors
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PDE4D SNPs may confer hypertension-modified stroke risk in elderly white women; hypothesis-generating and requires prospective validation.
Are Phosphodiesterase 4D (PDE4D) polymorphisms associated with incident ischemic stroke in elderly white women, and does hypertension status modify this association?
PDE4D gene polymorphisms are associated with incident ischemic stroke in a US population of elderly white women, with the association being significantly modified by hypertension status.
Brophy et al. (2006) studied this question.
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