Why the study?
Are PDE4D gene polymorphisms associated with an increased risk of incident ischemic stroke in initially healthy white males?
Population
518 initially healthy white males from the Physicians' Health Study cohort
Comparison
Presence of nine PDE4D single nucleotide… vs Matched controls without ischemic stroke
Design
Case-control
Authors
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Does not support genetic testing for stroke risk stratification; hypothesis-generating for PDE4D variants in white men.
Are PDE4D gene polymorphisms associated with an increased risk of incident ischemic stroke in initially healthy white males?
Certain PDE4D gene polymorphisms, particularly SNP56, are modestly associated with an increased risk of incident ischemic stroke in white men, especially those without baseline hypertension.
Zee et al. (2006) studied this question.
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