Why the study?
Do PDE4D polymorphisms increase the risk of early-onset ischemic stroke in young women?
Population
435 women aged 15-49, biracial
Comparison
Phosphodiesterase 4D gene polymorphisms vs Absence of the risk polymorphism/allele
Design
Case-control
Authors
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Should not change clinical practice for stroke prevention; leaves open a PDE4D-smoking interaction in young women pending replication.
Do PDE4D polymorphisms increase the risk of early-onset ischemic stroke in young women?
The PDE4D polymorphism rs918592 is associated with an increased risk of early-onset ischemic stroke in young women, with the risk strongly amplified by current smoking.
Qing Song (2006) studied this question.
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