Association of Phosphodiesterase 4D With Ischemic Stroke
Key result
PDE4D gene variant rs2910829 is linked to higher risk of cardioembolic stroke across racial groups.
- n=839
Why the study?
Previous studies reported an association of PDE4D gene polymorphisms with ischemic stroke, but findings were inconsistent and lacked significant representation of blacks.
Are Phosphodiesterase 4D (PDE4D) gene polymorphisms associated with ischemic stroke in a biracial population?
Population
357 ischemic stroke cases and 482 stroke-free controls from a biracial community-based population
Comparison
PDE4D gene polymorphisms in ischemic stroke cases versus stroke-free controls
Design
Population-based biracial case-control study
Authors
Discussion
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Member takes
Implication
Supports PDE4D association with cardioembolic stroke across ancestries; hypothesis-generating and requires replication before clinical use.
Study Design
Type
Case-Control (n=839)
Structured PICO
Are Phosphodiesterase 4D (PDE4D) gene polymorphisms associated with ischemic stroke in a biracial population?
P
Population
839 individuals comprising 357 ischemic stroke cases and 482 stroke-free controls from a biracial community.
E
Exposure
Phosphodiesterase 4D (PDE4D) gene polymorphisms (SNPs and haplotypes)
C
Comparator
Stroke-free controls
O
Outcome
Association with ischemic stroke and its subtypes (cardioembolic, small vessel, unknown origin)hard clinical
PDE4D gene polymorphisms are associated with ischemic stroke, particularly cardioembolic stroke, in both white and black populations.
Cite This Study
Woo et al. (2005) conducted a case-control in Ischemic stroke (n=839). PDE4D gene polymorphisms vs. Stroke-free controls was evaluated on Ischemic stroke and its subtypes. PDE4D gene polymorphisms, specifically SNP rs2910829, were significantly associated with cardioembolic stroke among both white and black individuals.