Key result
The DD genotype of the ACE I/D polymorphism was independently associated with a higher severity of coronary artery disease (Gensini score β 7.742) compared to II or ID genotypes in Vietnamese patients with acute myocardial infarction.
Why the study?
Coronary artery disease severity predicts major adverse cardiovascular events in acute myocardial infarction, and ACE I/D polymorphism may affect this severity.
Does the ACE DD genotype associate with increased severity of coronary artery disease in Vietnamese patients with acute myocardial infarction?
Observational (n=522)
No
Does the ACE DD genotype associate with increased severity of coronary artery disease in Vietnamese patients with acute myocardial infarction?
The ACE DD genotype is independently associated with more severe coronary artery disease, as measured by the Gensini score, in Vietnamese patients presenting with their first acute myocardial infarction.
Answers are grounded in this paper and cite their sources.
May support CAD severity stratification by ACE genotype in Vietnamese AMI; hypothesis-generating and should not yet change practice.
Background The severity of coronary artery disease is a prognostic factor for major adverse cardiovascular events in patients diagnosed with acute myocardial infarction. ACE I/D polymorphism is one of the genetic factors that may affect the severity of coronary artery disease. This study aimed to investigate the association between ACE I/D genotypes and the severity of coronary artery disease in patients with acute myocardial infarction. Materials and methods A single-center, prospective, observational study was conducted at the Department of Cardiology and Department of Interventional Cardiology, Cho Ray Hospital, Ho Chi Minh City, Vietnam from January 2020 to June 2021. All participants diagnosed with acute myocardial infarction underwent contrast-enhanced coronary angiography. The severity of coronary artery disease was determined by Gensini score. ACE I/D genotypes were identified in all subjects by using the polymerase chain reaction method. Results A total of 522 patients diagnosed with first acute myocardial infarction were recruited. The patients' median Gensini score was 34.3. The II, ID, and DD genotype rates of ACE I/D polymorphism were 48.9%, 36.4%, and 14.7%, respectively. After adjusting for confounding factors, multivariable linear regression analysis showed that the ACE DD genotype was independently associated with a higher Gensini score compared with the II or ID genotypes. Conclusion The DD genotype of the ACE I/D polymorphism was associated with the severity of coronary artery disease in Vietnamese patients diagnosed with first acute myocardial infarction.
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Tran et al. (2023) conducted an observational in Acute myocardial infarction (n=522). ACE I/D genetic polymorphism (DD genotype) vs. II or ID genotypes was evaluated on Severity of coronary artery disease (Gensini score) (β 7.742, 95% CI 0.251-15.233, p=0.043). The DD genotype of the ACE I/D polymorphism was independently associated with a higher severity of coronary artery disease (Gensini score β 7.742) compared to II or ID genotypes in Vietnamese patients with acute myocardial infarction.
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