Why the study?
Does penbutolol compared to propranolol affect glomerular filtration rate in patients with hypertension and impaired renal function?
Does penbutolol compared to propranolol affect glomerular filtration rate in patients with hypertension and impaired renal function?
In hypertensive patients with impaired renal function, neither penbutolol nor propranolol significantly altered GFR, though propranolol caused a 10% increase in serum creatinine.
Neither beta-blocker impairs measured GFR in hypertensive patients with renal impairment; confirms serum creatinine may rise independently of true GFR with propranolol.
Penbutolol and propranolol were administered orally in a dosage of 40 mg once daily and 80 mg twice daily, respectively to 12 patients with hypertension and impaired renal function. Both drugs caused a significant decrease in mean arterial pressure and heart rate. Serum creatinine concentration increased significantly by 10% during therapy with propranolol without concomitant decrease in creatinine clearance. No such effect was seen with penbutolol. GFR measured with [125I]-iothalamate showed no significant changes with both drugs.
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Meulen et al. (1986) studied this question.
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