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January 1, 1991Journal of Cardiovascular Pharmacology

Production of Endothelin by Vascular Smooth Muscle Cells

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Population

Cultured vascular smooth muscle cells isolated from rat and rabbit aortae, and endothelial cells

Comparison

Calcitonin gene-related peptide, vasoactive… vs Basal conditions (untreated cells)

Design

Preclinical

Authors

SKSandip M. KanseUniversity of OsloKTKazuhiro TakahashiTeikyo University HospitalJWJ. B. WarrenRoyal Society of Medicine

Discussion

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Implication

Hypothesis-generating for neuropeptide modulation of vascular ET; leaves open translation to human disease models.

Structured PICO

P
Population
Cultured vascular smooth muscle cells isolated from rat and rabbit aortae, and endothelial cells
I
Intervention
Calcitonin gene-related peptide (CGRP), vasoactive intestinal polypeptide (VIP), forskolin, and dibutryl-cAMP
C
Comparator
Basal conditions (untreated cells)
O
Outcome
Endothelin (ET) production rate and ET receptor densitysurrogate

Vascular smooth muscle cells produce low levels of endothelin-1, which is suppressed by CGRP and VIP, suggesting an autocrine function regulated by perivascular neuropeptides.

Cite This Study

Kanse et al. (1991) studied this question.

synapsesocial.com/papers/6a75184ea44b96c1f7dbee05https://doi.org/10.1097/00005344-199100177-00029
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stimulation of endothelin mRNA and secretion in rat vascular smooth muscle cells: a novel autocrine function.1990 · 267 citations
  2. 2Secretion of endothelin‐1 and endothelin‐3 by human cultured vascular smooth muscle cells1995 · 72 citations
  3. 3Endothelin ETA receptor expression in human cerebrovascular smooth muscle cells1995 · 40 citations
  4. 4Delineation of Endothelin Receptors in Human Left Ventricular Smooth-Muscle Cells1995 · 10 citations
  5. 5Endothelin stimulates phosphatidylinositol hydrolysis and DNA synthesis in brain capillary endothelial cells1990 · 150 citations