Why the study?
It was hypothesized that peak oxygen consumption adjusted for lean body mass (VO2 lean) is a superior independent prognostic predictor in HFpEF compared to traditional CPET measures.
Does VO2 lean measured by CPET predict the composite of all-cause mortality and HF hospitalizations in patients with HFpEF better than traditional CPET measures?
Population
103 outpatient HFpEF patients at a Brazilian tertiary hospital
Comparison
VO2 lean vs traditional CPET measures
Design
Prospective cohort study
Follow-up
Average of 889 days (±291)
Key result
Peak oxygen consumption adjusted for lean body mass (VO2 lean) was an independent predictor of all-cause mortality and heart failure hospitalization in patients with HFpEF (HR 0.912; p<0.025).
Authors
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VO2 lean may aid HFpEF risk stratification; leaves open whether it outperforms standard CPET metrics prospectively.
Cohort (n=103)
No
Does VO2 lean measured by CPET predict the composite of all-cause mortality and HF hospitalizations in patients with HFpEF better than traditional CPET measures?
Hazard Ratio: 0.912
p-value: p=<0.025
VO2 lean measured during cardiopulmonary exercise testing is a strong independent predictor of mortality and heart failure hospitalization in patients with HFpEF, outperforming traditional CPET measures.
Barros et al. (2026) conducted a cohort in Heart failure with preserved ejection fraction (HFpEF) (n=103). Peak oxygen consumption adjusted for lean body mass (VO2 lean) was evaluated on Composite of all-cause mortality and HF hospitalizations (HR 0.912, p=<0.025). Peak oxygen consumption adjusted for lean body mass (VO2 lean) was an independent predictor of all-cause mortality and heart failure hospitalization in patients with HFpEF (HR 0.912; p<0.025).
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