Myocardial fibrosis in patients with a history of Kawasaki disease
Why the study?
It was unknown whether myocardial fibrosis, assessed by CMR measurements of extracellular volume fraction and late gadolinium enhancement, is increased in patients with a history of Kawasaki disease compared to controls.
Do patients with a history of Kawasaki disease have increased myocardial fibrosis measured by CMR compared to normal controls?
Population
13 patients with Kawasaki disease and 20 control subjects
Comparison
Patients with a history of Kawasaki disease vs controls
Design
Single-center retrospective study
Authors
Discussion
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Member takes
Implication
Does not support routine CMR fibrosis screening in KD; leaves open LGE significance and need for prospective outcome studies.
Structured PICO
Do patients with a history of Kawasaki disease have increased myocardial fibrosis measured by CMR compared to normal controls?
P
Population
33 subjects total: 13 patients with a history of Kawasaki disease (median age 14.9 years, range 7.5-36.0; 12 with coronary aneurysms) and 20 control subjects (median age 16 years, range 11.0-36.0).
I
Intervention
Cardiac magnetic resonance (CMR) with measurement of myocardial extracellular volume fraction (ECV) and late gadolinium enhancement (LGE)
C
Comparator
20 normal control subjects
O
Outcome
Myocardial extracellular volume fraction (ECV) and presence of focal fibrosis by late gadolinium enhancement (LGE)surrogate
While diffuse myocardial fibrosis (ECV) is not significantly increased in patients with a history of Kawasaki disease compared to controls, focal fibrosis (LGE) is a common finding.
Limitations
- Small sample size
Cite This Study
Dusenbery et al. (2021) studied this question.