January 9, 2025Open Access
Sex differences in the association between age-related decline in blood pressure and decline in cognition: A prospective cohort study
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Why the study?
Both high and declining blood pressure are associated with cognitive decline in older adults, but sex differences in the association between blood pressure decline and cognitive decline remain unknown.
Is age-related decline in blood pressure associated with cognitive decline differently in older men and women?
Population
4719 older adults without known baseline dementia enrolled in five US prospective community-based cohorts
Comparison
Association between blood pressure decline and cognitive decline compared between women and men
Design
Prospective cohort study
Follow-up
Up to 31 years (mean = 8.7 [SD = 5.7] years)
Authors
Discussion
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Implication
BP decline may signal higher cognitive risk in older women; leaves open whether sex-specific BP targets alter trajectories.
Structured PICO
Is age-related decline in blood pressure associated with cognitive decline differently in older men and women?
P
Population
4,719 older adults without known baseline dementia (mean age 76.7, 74% women) enrolled in one of five US-based prospective community-based cohort studies.
I
Intervention
Age-related decline in blood pressure (exposure)
O
Outcome
Change in global cognition (measured by a 19-test cognitive battery yielding a composite global score)surrogate
In older adults, declining systolic blood pressure is significantly correlated with global and domain-specific cognitive decline in women, but not in men.
Cite This Study
Baumgartner et al. (2025) studied this question.
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