Why the study?
Does SM-20550 improve mitochondrial function and prevent Ca2+ overload in isolated rat hearts subjected to ischemia/reperfusion?
Population
Isolated rat hearts subjected to 40 min of ischemia and 20 min of reperfusion
Comparison
SM-20550 administered for 5 min prior to… vs Untreated ischemic/reperfused rat hearts
Design
Preclinical
Follow-up
20 min of reperfusion
Authors
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Animal data on SM-20550 mitochondrial protection remain hypothesis-generating; leaves open any human translation or clinical testing.
Does SM-20550 improve mitochondrial function and prevent Ca2+ overload in isolated rat hearts subjected to ischemia/reperfusion?
The Na+/H+ exchange inhibitor SM-20550 protects mitochondrial function and improves postischemic recovery of left ventricular function by preventing mitochondrial Ca2+ overload in a rat model.
Yamamoto et al. (2002) studied this question.
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