June 1, 2000Journal of Cardiovascular Pharmacology

SM-20550, a New Na+/H+ Exchange Inhibitor and Its Cardioprotective Effect in Ischemic/Reperfused Isolated Rat Hearts by Preventing Ca2+-Overload

View Full Paper

Ask AI

Bookmark

Population

Rat cardiomyocytes and isolated perfused rat hearts exposed to 40 min of global ischemia and 20 min of…

Comparison

SM-20550 (10(-8)-10(-7) M) vs Control (implied)

Design

Preclinical

Follow-up

20 min of reperfusion

Authors

SYSetsuko YamamotoSumitomo Chemical (Japan)KMKazuki MatsuiKyoto University MKMasahumi Kitano

Discussion

Member takes

Implication

SM-20550 attenuates rat I/R injury; leaves open clinical translation of NHE inhibition.

Structured PICO

Population

Rat cardiomyocytes and isolated perfused rat hearts exposed to 40 min of global ischemia and 20 min of reperfusion

Intervention

SM-20550 (10(-8)-10(-7) M)

Comparator

Control (implied)

Outcome

Left ventricular end-diastolic pressure, postischemic recovery of developed pressure, and coronary perfusion pressure during reperfusionsurrogate

SM-20550 is a potent Na+/H+ exchange inhibitor that protects against myocardial ischemia/reperfusion injury by preventing Na+ and Ca2+ overload in a rat model.

Cite This Study

Yamamoto et al. (2000) studied this question.

synapsesocial.com/papers/6a756593b35e02fb15034afe https://doi.org/10.1097/00005344-200006000-00005

View Full Paper

Ask AI

Bookmark

SM-20550, a New Na+/H+ Exchange Inhibitor and Its Cardioprotective Effect in Ischemic/Reperfused Isolated Rat Hearts by Preventing Ca2+-Overload

Discussion

Member takes

Implication

Structured PICO

Cite This Study

SM-20550, a New Na+/H+ Exchange Inhibitor and Its Cardioprotective Effect in Ischemic/Reperfused Isolated Rat Hearts by Preventing Ca2+-Overload

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider