Why the study?
Subclinical and clinical thrombosis of bioprosthetic cardiac valves is more common than previously recognized, with limited reports in complex thrombophilic settings.
This case suggests the need for increased screening for prothrombotic risk factors in female patients with bioprosthetic valves before commencing gonadotropin stimulation therapy.
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Raises caution for bioprosthetic valve thrombosis during IVF in thrombophilic patients; leaves open true incidence and screening needs.
Subclinical and clinical thrombosis of bioprosthetic cardiac valves is more common than has been previously recognized. We present a unique case of acute thrombosis of a bioprosthetic mitral valve in a 40-year-old female patient undergoing hormonal stimulation as part of in vitro fertilization therapy, who also had concomitant protein C deficiency that was undiagnosed at the time. To the best of our knowledge, this is the first reported case of acute bioprosthetic valve thrombosis in this complex thrombophilic milieu, and suggests the need for increased screening for prothrombotic risk factors in female patients with bioprosthetic valves before they commence gonadotropin stimulation therapy.
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Quattrocchi et al. (2019) studied this question.
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