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February 15, 1963Science

Vascular Smooth Muscle: Dual Effect of Calcium

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Population

Rabbit aorta

Comparison

Elevation of calcium concentration vs Baseline/lower calcium concentration

Design

Preclinical

Authors

DBDavid F. BohrNHS Blood and Transplant

Discussion

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Overview

Dual calcium effects on rabbit aortic responses warrant no clinical extrapolation; leaves open relevance to human vascular tone or therapy.

Structured PICO

P
Population
Rabbit aorta
I
Intervention
Elevation of calcium concentration
C
Comparator
Baseline/lower calcium concentration
O
Outcome
Contractile response to epinephrinesurrogate

In rabbit aorta, elevated calcium exerts a dual effect on epinephrine-induced contraction by depressing initial membrane excitability and potentiating subsequent excitation-contraction coupling.

Cite This Study

David F. Bohr (1963) studied this question.

synapsesocial.com/papers/6a757e0ddcfefe9676dd770ahttps://doi.org/10.1126/science.139.3555.597
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Calcium movements during potassium contracture in isolated rabbit aortic strips1962 · 76 citations
  2. 2Calcium effect on performance of the heart1962 · 44 citations
  3. 3Na+, K+, Ca++, and Mg++ action on coronary vascular resistance in the dog heart1961 · 53 citations
  4. 4VAGAL AND SYMPATHETIC EFFECTS ON THE PACEMAKER FIBERS IN THE SINUS VENOSUS OF THE HEART1956 · 363 citations
  5. 5Dual contractile response of the aorta strip1959 · 28 citations