May 1, 2002Pharmacology & ToxicologyOpen Access

Drug‐Induced Ventricular Tachyarrhythmia in Isolated Rabbit Hearts with Atrioventricular Block

View Full Paper

Ask AI

Bookmark

Population

Isolated rabbit hearts with atrioventricular block

Comparison

Perfusion with d,l-sotalol, cisapride, mosapride… vs Comparison between drugs and between normal vs…

Design

Preclinical

Authors

YKYoshihide KiiSumitomo Dainippon Pharma (Japan)TITsugutaka ItoSumitomo Dainippon Pharma (Japan)

Discussion

Member takes

Implication

Suggests mosapride as lower-risk prokinetic in arrhythmia models; hypothesis-generating and requires clinical validation.

Structured PICO

Population

Isolated rabbit hearts with atrioventricular block

Intervention

Perfusion with d,l-sotalol (10 and 30 microM), cisapride (0.1 and 0.3 microM), mosapride citrate (1, 3, and 10 microM), or des-4-fluorobenzyl-mosapride (10 microM) in normal or low K/Mg solutions

Comparator

Comparison between drugs and between normal (K+=5.7 mM, Mg2+=1 mM) vs low (K+=1.5 mM, Mg2+=0.35 mM) K/Mg solutions

Outcome

Proarrhythmic potential (prolongation of ventricular repolarization, early after-depolarization, and polymorphic ventricular tachyarrhythmia)surrogate

Isolated rabbit hearts with AV block perfused with low K/Mg solution serve as a suitable model for predicting drug-induced proarrhythmia, demonstrating that mosapride has a safer electrophysiological profile than cisapride.

Cite This Study

Kii et al. (2002) studied this question.

synapsesocial.com/papers/6a7588a0756843cacbb20fc0 https://doi.org/10.1034/j.1600-0773.2002.900504.x

View Full Paper

Ask AI

Bookmark

Drug‐Induced Ventricular Tachyarrhythmia in Isolated Rabbit Hearts with Atrioventricular Block

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Drug‐Induced Ventricular Tachyarrhythmia in Isolated Rabbit Hearts with Atrioventricular Block

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider