Why the study?
Does TS-951 affect action potential parameters in isolated rabbit myocardium compared to cisapride?
Population
Isolated rabbit myocardium (Purkinje fiber, ventricular muscle, sinoatrial node, and right atria)
Comparison
TS-951 vs Cisapride
Design
Preclinical
Authors
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May indicate lower proarrhythmic potential for TS-951 than cisapride; hypothesis-generating for clinical use and should not yet change practice.
Does TS-951 affect action potential parameters in isolated rabbit myocardium compared to cisapride?
TS-951, unlike cisapride, does not prolong action potential duration in ventricular myocardium, suggesting a lower risk of QT prolongation and torsades de pointes.
Noguchi et al. (2001) studied this question.
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