Key result
Cisapride prolongs APD without involving 5-HT or alpha-1 receptors while mosapride has no effect.
Why the study?
Do 5-HT4-receptor agonists affect action potential duration in guinea pig isolated papillary muscles?
Population
Guinea pig isolated papillary muscles
Comparison
5-HT4-receptor agonists vs Antagonists and clofilium
Design
Preclinical
Authors
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May support mosapride preference over cisapride to limit APD effects in models; leaves open human QT translation.
Do 5-HT4-receptor agonists affect action potential duration in guinea pig isolated papillary muscles?
Cisapride prolongs cardiac action potential duration independently of 5-HT receptors, whereas mosapride does not, indicating a lower risk of QT prolongation for mosapride.
Kii et al. (1997) studied this question. 5-HT4-receptor agonists (cisapride, mosapride citrate, zacopride) was evaluated on Action potential duration (APD). Cisapride prolonged action potential duration without involvement of 5-HT2, 5-HT4, or alpha 1 receptors, whereas mosapride did not affect action potentials at 10 microM.
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