Key result
Cisapride prolonged QT and QTc intervals across multiple animal models, whereas mosapride had little to no significant effect on QTc, indicating mosapride has little arrhythmogenic potential.
Population
Anaesthetized rats, anaesthetized guinea-pigs, and conscious cats
Design
Preclinical
Follow-up
Up to 7 days
Authors
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Mosapride may be preferable to cisapride for QT safety; animal data leave human arrhythmogenic risk open.
In animal models, mosapride citrate lacks the significant QT-prolonging arrhythmogenic effects observed with cisapride.
Kii et al. (2001) studied Arrhythmogenic potential. Cisapride and Mosapride citrate was evaluated on Electrocardiographic RR, QT, and QTc intervals. Cisapride prolonged QT and QTc intervals across multiple animal models, whereas mosapride had little to no significant effect on QTc, indicating mosapride has little arrhythmogenic potential.
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