Cloning and Expression of cDNA Encoding a Rat Adrenomedullin Receptor
Population
Rat lung tissue (source of orphan receptor cDNA) and COS-7 cells (used for expression)
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Cloned receptor enables molecular studies of adrenomedullin signaling; leaves open its cardiovascular roles pending in vivo validation.
Structured PICO
P
Population
Rat lung tissue (source of orphan receptor cDNA) and COS-7 cells (used for expression)
I
Intervention
Cloning and expression of a cDNA encoding a 395-residue G protein-coupled receptor
O
Outcome
cAMP response and binding affinity to adrenomedullinsurrogate
The cloning of the rat adrenomedullin receptor enables further molecular and physiological studies of its role in cardiovascular regulation.
Cite This Study
Kapas et al. (1995) studied this question.