Why the study?
Does valsartan prevent reflex sympathetic activation compared to amlodipine or placebo in patients with primary hypertension?
Population
18 hypertensive but otherwise healthy subjects with moderate primary hypertension
Comparison
Valsartan for 7 days vs Amlodipine or placebo for 7 days
Design
RCT, randomized sequence, double-blind, placebo-controlled
Follow-up
7 days per treatment period
Authors
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Valsartan lowers BP without reflex sympathetic activation unlike amlodipine; confirms class-specific autonomic neutrality of ARBs in hypertension.
Does valsartan prevent reflex sympathetic activation compared to amlodipine or placebo in patients with primary hypertension?
Selective angiotensin II receptor blockade with valsartan lowers blood pressure without causing the reflex sympathetic activation seen with the calcium channel blocker amlodipine.
Struck et al. (2002) studied this question.
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