Why the study?
Does valsartan improve basal NO production and endothelium-dependent vasodilation in patients with essential hypertension?
Population
60 patients with essential hypertension, mean age 53 +/- 10 years
Comparison
Valsartan 80 mg once daily for 6 weeks vs Hydrochlorothiazide 25 mg once daily or placebo…
Design
RCT, randomized, double-blind
Follow-up
6 weeks
Authors
Loading...
Valsartan enhances basal NO production beyond BP reduction in hypertension; extends evidence for AT1 blockade's endothelial benefits.
Does valsartan improve basal NO production and endothelium-dependent vasodilation in patients with essential hypertension?
AT1 receptor blockade with valsartan improves basal nitric oxide production and release in patients with essential hypertension, an effect that appears independent of blood pressure reduction.
Arnfried U. Klingbeil (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: