January 1, 1998Microvascular ResearchOpen Access

Vasomotion and Spontaneous Low-Frequency Oscillations in Blood Flow and Nitric Oxide in Cat Optic Nerve Head

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Structured PICO

Population

16 cats (optic nerve head model)

Intervention

Nitric oxide (NO) synthase inhibitors (l-nitroarginine [L-NA], n=6; l-nitroarginine methyl ester [L-NAME], n=5)

Comparator

Baseline (pre-administration)

Outcome

Power spectral densities for the magnitude and frequency of laser Doppler flowmetry (LDF) and NO fluctuationssurrogate

Nitric oxide is not required for vasomotion in the cat optic nerve head, suggesting that spontaneous low-frequency NO fluctuations are a passive phenomenon caused by natural variations in shear stresses.

Discussion

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Implication

Hypothesis-generating for NO-independent vasomotion in optic nerve; leaves clinical translation to humans open.

Cite This Study

Buerk et al. (1998) studied this question.

synapsesocial.com/papers/6a759869d17bc701ee161019 https://doi.org/10.1006/mvre.1997.2053

View Full Paper

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Vasomotion and Spontaneous Low-Frequency Oscillations in Blood Flow and Nitric Oxide in Cat Optic Nerve Head

Structured PICO

Discussion

Implication

Cite This Study

Vasomotion and Spontaneous Low-Frequency Oscillations in Blood Flow and Nitric Oxide in Cat Optic Nerve Head

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider