Why the study?
Does lead exposure alter intrinsic vascular reactivity in Sprague-Dawley rats?
Does lead exposure alter intrinsic vascular reactivity in Sprague-Dawley rats?
Lead-induced hypertension in rats appears to be driven by circulating factors or hemodynamic changes rather than intrinsic alterations in vascular reactivity.
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Suggests systemic factors may drive lead hypertension in rats; hypothesis-generating with no human applicability yet.
Ralph E. Purdy (1997) studied this question.
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