Population
Isolated left ventricular papillary muscle preparations from male spontaneously hypertensive rats and…
Comparison
Hypoxia for up to 60 min with varying glucose… vs Oxygenated conditions and normotensive WKY rats
Design
Preclinical
Follow-up
up to 60 minutes of hypoxia followed by reoxygenation
Authors
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Aged SHR show glucose-mitigable hypoxic vulnerability; hypothesis-generating for metabolic cardioprotection in hypertensive models, not yet clinically actionable.
Aged spontaneously hypertensive rats exhibit reduced myocardial tolerance to prolonged hypoxia, which can be mitigated by increased glucose availability.
Brooks et al. (1987) studied this question.
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