Key result
Preoperative oral sildenafil significantly reduced systolic pulmonary artery pressure (54.20 vs 70.90 mmHg, p<0.0001) compared to placebo in patients with severe pulmonary hypertension undergoing mitral valve replacement.
Why the study?
Does preoperative oral sildenafil reduce pulmonary artery pressure and improve postoperative outcomes in patients with severe pulmonary hypertension undergoing mitral valve replacement?
Population
40 patients scheduled for mitral valve replacement surgery with severe pulmonary hypertension. Excluded…
Comparison
Oral sildenafil 25 mg three times a day for 24… vs Placebo three times a day for 24 hours before…
Design
RCT, Computerized randomization table, Double-blind
Follow-up
6 hours postoperatively for hemodynamics, plus duration of…
Authors
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Supports preoperative sildenafil to lower PAP and shorten recovery in severe PH undergoing MVR; extends perioperative evidence in this surgical population.
RCT (n=40)
Double-blind
Computerized randomization table
No
Does preoperative oral sildenafil reduce pulmonary artery pressure and improve postoperative outcomes in patients with severe pulmonary hypertension undergoing mitral valve replacement?
Absolute Event Rate: 54.2% vs 70.9%
p-value: p=<0.0001
Preoperative oral sildenafil significantly reduces pulmonary artery pressure and pulmonary vascular resistance, and decreases ventilation and ICU stay times in patients with severe pulmonary hypertension undergoing mitral valve replacement.
Shastri et al. (2014) conducted an RCT in Severe pulmonary artery hypertension in mitral valve disease (n=40). Oral sildenafil vs. Placebo was evaluated on Systolic pulmonary artery pressure (SPAP) 20 minutes after insertion of pulmonary artery catheter under anesthesia (T1) (p=<0.0001). Preoperative oral sildenafil significantly reduced systolic pulmonary artery pressure (54.20 vs 70.90 mmHg, p<0.0001) compared to placebo in patients with severe pulmonary hypertension undergoing mitral valve replacement.
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