Why the study?
Severe pulmonary hypertension increases morbidity and mortality in mitral valve surgery, but evidence of the usefulness of sildenafil in pulmonary hypertension due to mitral valve disease is lacking.
Does preoperative oral sildenafil improve intraoperative hemodynamics and reduce recovery time in patients with severe pulmonary hypertension undergoing mitral valve replacement?
Population
50 patients with severe pulmonary hypertension undergoing mitral valve replacement
Comparison
Oral sildenafil 25 mg eight hourly for 48 hours vs placebo
Design
Randomized controlled trial
Follow-up
6 hours postoperatively
Authors
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Preoperative oral sildenafil significantly improves pulmonary hemodynamics and reduces ventilation and recovery times in patients with severe pulmonary hypertension undergoing mitral valve replacement.
Does preoperative oral sildenafil improve intraoperative hemodynamics and reduce recovery time in patients with severe pulmonary hypertension undergoing mitral valve replacement?
Preoperative oral sildenafil significantly improves pulmonary hemodynamics and reduces ventilation and recovery times in patients with severe pulmonary hypertension undergoing mitral valve replacement.
Vijay Shewale (2020) studied this question.
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