Why the study?
Sildenafil has proven benefit in pulmonary arterial hypertension but discordant results in group 2 pulmonary hypertension, leaving its effect on intra-operative hemodynamics during mitral valve surgery unclear.
Does pre-operative sildenafil improve intra-operative hemodynamic parameters in adult patients with pulmonary hypertension undergoing mitral valve surgery?
Population
153 patients with pulmonary hypertension undergoing mitral valve surgery across 3 studies
Comparison
Pre-operative sildenafil vs comparator
Design
Systematic review and meta-analysis of randomized controlled trials
Authors
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Supports pre-operative sildenafil consideration in pulmonary hypertension patients for mitral valve surgery; extends evidence for perioperative sPAP management.
Does pre-operative sildenafil improve intra-operative hemodynamic parameters in adult patients with pulmonary hypertension undergoing mitral valve surgery?
Pre-operative sildenafil effectively lowers systolic pulmonary arterial pressure during and after mitral valve surgery in patients with pulmonary hypertension, without compromising systemic hemodynamics.
Villanueva et al. (2019) studied this question.
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