Key result
Pressor responses (systolic blood pressure increase ≥10 mmHg) were more common with antirenin drugs than with diuretics (11% vs. 5%, P=0.001), supporting renin-guided hypertension treatment.
Why the study?
Does renin-guided antihypertensive treatment improve systolic blood pressure reduction in hypertensive patients?
Does renin-guided antihypertensive treatment improve systolic blood pressure reduction in hypertensive patients?
Absolute Event Rate: 11% vs 5%
p-value: p=0.001
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Stratifying hypertensive patients by plasma renin activity to guide drug selection may optimize blood pressure control and prevent paradoxical pressor responses.
Curt D. Furberg (2010) conducted an editorial in Hypertension. Antirenin drugs vs. Diuretics was evaluated on Pressor response (increase in systolic blood pressure of ≥10 mmHg) (p=0.001). Pressor responses (systolic blood pressure increase ≥10 mmHg) were more common with antirenin drugs than with diuretics (11% vs. 5%, P=0.001), supporting renin-guided hypertension treatment.
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