Mechanism and modification of bradykinin-induced coronary vasodilation.
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Why the study?
Does bradykinin induce coronary vasodilation via prostaglandin biosynthesis in isolated rabbit hearts?
Population
Isolated perfused rabbit (New Zealand) hearts
Comparison
Bradykinin injection vs Baseline/control without inhibitors
Design
Preclinical
Authors
Discussion
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Implication
Hypothesis-generating for prostaglandin mediation of bradykinin coronary effects; leaves open translation to human ischemia or reflexes.
Structured PICO
Does bradykinin induce coronary vasodilation via prostaglandin biosynthesis in isolated rabbit hearts?
P
Population
Isolated perfused rabbit (New Zealand) hearts
I
Intervention
Bradykinin injection (with or without SQ-20881 or indomethacin)
C
Comparator
Baseline/control without inhibitors
O
Outcome
Coronary resistance and release of prostaglandin-E-like substancesurrogate
Bradykinin-induced coronary vasodilation is mediated by endogenous prostaglandin biosynthesis, which may play a role in cardiovascular reflexes and pain during myocardial ischemia.
Cite This Study
Needleman et al. (1975) studied this question.
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