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July 1, 1993AJP Cell Physiology

Whole cell Cl- currents in human neutrophils induced by cell swelling

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Population

Human neutrophils

Design

Preclinical

Authors

JSJ. S. StoddardUniversity of Illinois Urbana-ChampaignJSJoe Henry SteinbachWashington University in St. LouisLSL SimchowitzNational Institutes of Health

Discussion

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Implication

Should not change clinical practice; leaves open stretch-sensitive Cl- channels as regulators of neutrophil volume decrease.

Structured PICO

P
Population
Human neutrophils
I
Intervention
Cell swelling induced by hyperosmotic patch pipette solution (addition of sucrose)
O
Outcome
Properties of conductive Cl- transport pathway (Cl- currents, activation, permeability, single-channel conductance, blockade)surrogate

The initial event triggering regulatory volume decrease in human neutrophils may be the activation of stretch-sensitive Cl- channels in the plasma membrane.

Cite This Study

Stoddard et al. (1993) studied this question.

synapsesocial.com/papers/6a75b942b1c5cc4eb2b1cd80https://doi.org/10.1152/ajpcell.1993.265.1.c156
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