Why the study?
Do different digitalis glycosides have different rapidities of onset of inotropic effect in normal subjects?
Population
55 normal volunteer subjects
Comparison
Intravenous injection of digitalis glycosides vs Comparison among the different digitalis…
Design
Other
Follow-up
Serial measurements following intravenous injection
Authors
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May inform acute digitalis selection in normal subjects; leaves open relevance to contemporary HF outcomes.
Do different digitalis glycosides have different rapidities of onset of inotropic effect in normal subjects?
Ouabain and cedilanid-D have a significantly more rapid onset of inotropic activity compared to digoxin and digitoxin in normal subjects.
Forester et al. (1974) studied this question.
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