Why the study?
Does enalapril reduce hypertension in pregnant rats with chronic reductions in uterine perfusion pressure?
Population
Conscious chronically instrumented pregnant rats, with and without chronic reductions in uterine perfusion…
Comparison
Chronic oral administration of a… vs Control (no enalapril)
Design
Preclinical
Follow-up
6 days
Authors
Loading...
Enalapril fails to blunt hypertension in pregnant RUPP rats; leaves open RAS-independent mechanisms and precludes extrapolation to human preeclampsia.
Does enalapril reduce hypertension in pregnant rats with chronic reductions in uterine perfusion pressure?
The renin-angiotensin system does not play a major role in mediating hypertension produced by chronic reductions in uterine perfusion pressure in pregnant rats.
Alexander et al. (2001) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: