Why the study?
Does ZD 7155 reduce angiotensin II-induced pressor actions compared to losartan in normotensive and hypertensive rats?
Does ZD 7155 reduce angiotensin II-induced pressor actions compared to losartan in normotensive and hypertensive rats?
ZD 7155 is a novel angiotensin II type 1 receptor antagonist that demonstrates approximately ten times greater potency than losartan in suppressing angiotensin II-induced pressor responses in a rat model.
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ZD 7155's greater rat potency supports further preclinical work; leaves open human translation and dosing.
Junggren et al. (1996) studied this question.
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