Why the study?
Do CoQ10 and vitamin E alter serum sialic acid and trace element levels in doxorubicin-induced rats?
Do CoQ10 and vitamin E alter serum sialic acid and trace element levels in doxorubicin-induced rats?
In a rat model of doxorubicin administration, vitamin E and CoQ10 supplementation altered trace element profiles, particularly increasing copper levels, which may relate to oxidative damage.
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Vitamin E with doxorubicin raises copper in rats; hypothesis-generating for trace element effects on cardiotoxicity, no clinical implications.
This study was designed to evaluate the effect of CoQ(10) and vitamin E on serum total sialic acid (TSA), lipid bound sialic acid (LSA) and some elements in rat administered doxorubicin (DXR). Cu levels were increased in the group treated with DXR + vitamin E in comparison with DXR (p<0.05) and CoQ(10) groups (p = 0.001). Furthermore, copper levels were increased in the group treated with DXR + CoQ10 in comparison with CoQ(10) group (p < 0.05). Zn levels were decreased in the group treated with DXR + vitamin E in comparison with CoQ(10) group (p < 0.05). Mg levels were decreased in subjects treated with DXR + vitamin E in comparison with the control group values (p < 0.05). Particularly, the observed increase in Cu levels in rats from DXR + vitamin E group might be due to the decrease of vitamin E. However, the oxidative damage could be as a result of DXR occurence and may be helpful to clinicians in chemotherapy using anthracycline.
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Oto et al. (2011) studied this question.
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