Why the study?
Do CRP gene polymorphisms correlate with serum CRP levels and arterial pulse wave velocity in healthy elderly Japanese subjects?
Population
315 healthy elderly Japanese subjects not taking any medication.
Comparison
C-reactive protein gene polymorphisms and… vs Different genotypes and haplotypes within the…
Design
Cross-sectional
Authors
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CRP polymorphisms associate with higher CRP and PWV in elderly Japanese; hypothesis-generating and requires prospective validation before clinical use.
Do CRP gene polymorphisms correlate with serum CRP levels and arterial pulse wave velocity in healthy elderly Japanese subjects?
Specific CRP gene polymorphisms and haplotypes are associated with elevated basal CRP levels and increased arterial stiffness in healthy elderly Japanese individuals, suggesting their potential utility as genetic markers for atherosclerosis susceptibility.
Morita et al. (2006) studied this question.
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